How should LLMs affect the practice of science?

Large language models (LLMs) are being increasingly incorporated into scientific workflows. However, we have yet to fully grasp the implications of this integration. How should the advancement of large language models affect the practice of science? For this opinion piece, we have invited four diverse groups of scientists to reflect on this query, sharing their […]

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Scaling Laws of Scientific Discovery with AI and Robot Scientists

The rapid evolution of scientific inquiry highlights an urgent need for groundbreaking methodologies that transcend the limitations of traditional research. Conventional approaches, bogged down by manual processes and siloed expertise, struggle to keep pace with the demands of modern discovery. We envision an autonomous generalist scientist (AGS) system-a fusion of agentic AI and embodied robotics-that […]

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Chatbots for Data Collection in Surveys

Surveys are a widespread method for collecting data at scale, but their rigid structure often limits the depth of qualitative insights obtained. While interviews naturally yield richer responses, they are challenging to conduct across diverse locations and large participant pools. To partially bridge this gap, we investigate the potential of using LLM-based chatbots to support […]

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Evaluating AI Models as Scientific Research Assistants

Recent advancements have positioned AI, and particularly Large Language Models (LLMs), as transformative tools for scientific research, capable of addressing complex tasks that require reasoning, problem-solving, and decision-making. Their exceptional capabilities suggest their potential as scientific research assistants but also highlight the need for holistic, rigorous, and domain-specific evaluation to assess effectiveness in real-world scientific […]

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A Computational Method for Measuring “Open Codes” in Qualitative Analysis

Qualitative analysis is critical to understanding human datasets in many social science disciplines. Open coding is an inductive qualitative process that identifies and interprets “open codes” from datasets. Yet, meeting methodological expectations (such as “as exhaustive as possible”) can be challenging. While many machine learning (ML)/generative AI (GAI) studies have attempted to support open coding, […]

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Beyond principlism: Practical strategies for ethical AI use in research practices

The rapid adoption of generative artificial intelligence (AI) in scientific research, particularly large language models (LLMs), has outpaced the development of ethical guidelines, leading to a “Triple-Too” problem: too many high-level ethical initiatives, too abstract principles lacking contextual and practical relevance, and too much focus on restrictions and risks over benefits and utilities. Existing approaches—principlism […]

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ChatGPT for Education Research: Qualitative Codebook Development

In qualitative data analysis, codebooks offer a systematic framework for establishing shared interpretations of themes and patterns. While the utility of codebooks is well-established in educational research, the manual process of developing and refining codes that emerge bottom-up from data presents a challenge in terms of time, effort, and potential for human error. This paper […]

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